Research Topic

Understanding Neural Circuits Using Single-Cell Technologies

About this Research Topic

Recent advances in single-cell sequencing technologies, including transcriptomic and multimodal analyses, are changing our understanding of the cellular building blocks of functional neural circuits. The new exciting discoveries updated taxonomies of neuronal or glial types and identification of cellular states and genes underlying development, aging, and diseases. The single-cell transcriptomes also provide insight into developmental and evolutionary relationships between cell populations across brain regions and species. Further innovation on single-cell techniques are underway for targeted functional studies of neuronal circuits, combining molecular markers with morphology, connectivity, neurochemistry, and physiology.

We welcome original research articles as well as review/minireview papers related to our topic. We also welcome novel data mining from published single-cell transcriptomic data to study neural circuits.

The Research Topic will cover different areas within PNS and CNS in both vertebrates and invertebrates (e. g, mice, Drosophila) using single-cell transcriptome with or without multiple modalities or spatial transcriptomics.

For example,

1. Diversity of neurons and neural circuits

2. Development and regeneration of neurons and neural circuits

3. Understanding cell states and plasticity using single-cell trajectory inference

4. Methods and algorithms to understand neural circuits using single-cell sequencing

5. Comparisons of neurons and neural circuits in different regions across different species

6. Evolution of neurons and neural circuits

7. Roles of glial cells and other cells in neural circuits

8. Neurons and neural circuits in neurological disorders

9. Pharmacology and neural circuits


Keywords: Single-Cell Sequencing, Neuroscience, Cell Types, Neural Circuits, Evolution


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent advances in single-cell sequencing technologies, including transcriptomic and multimodal analyses, are changing our understanding of the cellular building blocks of functional neural circuits. The new exciting discoveries updated taxonomies of neuronal or glial types and identification of cellular states and genes underlying development, aging, and diseases. The single-cell transcriptomes also provide insight into developmental and evolutionary relationships between cell populations across brain regions and species. Further innovation on single-cell techniques are underway for targeted functional studies of neuronal circuits, combining molecular markers with morphology, connectivity, neurochemistry, and physiology.

We welcome original research articles as well as review/minireview papers related to our topic. We also welcome novel data mining from published single-cell transcriptomic data to study neural circuits.

The Research Topic will cover different areas within PNS and CNS in both vertebrates and invertebrates (e. g, mice, Drosophila) using single-cell transcriptome with or without multiple modalities or spatial transcriptomics.

For example,

1. Diversity of neurons and neural circuits

2. Development and regeneration of neurons and neural circuits

3. Understanding cell states and plasticity using single-cell trajectory inference

4. Methods and algorithms to understand neural circuits using single-cell sequencing

5. Comparisons of neurons and neural circuits in different regions across different species

6. Evolution of neurons and neural circuits

7. Roles of glial cells and other cells in neural circuits

8. Neurons and neural circuits in neurological disorders

9. Pharmacology and neural circuits


Keywords: Single-Cell Sequencing, Neuroscience, Cell Types, Neural Circuits, Evolution


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

31 January 2022 Abstract
31 May 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

31 January 2022 Abstract
31 May 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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